As I stood in my kitchen, the aroma of sautéing garlic wafted through the air, instantly transporting me to a cozy gathering with friends, sharing laughter over steaming bowls of our favorite comfort food. Today, I’m excited to recreate that magic with my High-Protein Spinach and Artichoke Chicken Casserole. With 47 grams of protein per serving, this dish not only satisfies your taste buds but also keeps you feeling energized and full. It’s the perfect solution for busy weeknights when you crave something wholesome without spending hours in the kitchen. Combining creamy spinach, zesty artichokes, and tender chicken, this casserole is a delicious take on the classic dip you love, now transformed into a hearty meal. Curious how to whip up this nourishing delight? Let’s dive in!

Why is this casserole a game-changer?
Nutrient-Packed Delight: Each serving contains an impressive 47 grams of protein—perfect for post-workout recovery or family dinners.
Quick & Easy: With straightforward prep and just one baking dish, clean-up is a breeze!
Versatile Base: Feel free to switch up ingredients—try Greek yogurt instead of cottage cheese or throw in some extra veggies for added nutrition!
Crowd Pleaser: This dish is sure to be a hit at any gathering, just like Crack Chicken Noodles or Greek Chicken Casserole, keeping everyone satisfied.
Comfort Food Twist: It transforms your favorite dip into a nourishing meal that’s great for any night of the week!
Spinach and Artichoke Chicken Casserole Ingredients
• Get ready to create this delectable dish with these essential components!
For the Casserole
- Cottage Cheese (16 oz) – Provides creaminess and a high-protein boost; opt for 4% fat for best results.
- Garlic (2 cloves) – Adds a fragrant kick; peel and mince before use for even flavor distribution.
- Kosher Salt (½ tsp + to taste) – Enhances overall flavor; adjust to your preference for optimal taste.
- Black Pepper (¼ tsp + to taste) – Infuses warmth; freshly ground pepper adds the best spice.
- Onion Powder (¼ tsp) – Contributes savory depth; can be swapped with fresh onion for a different texture.
- Avocado Oil (1 tsp or olive oil) – Used for cooking chicken; olive oil is a fantastic alternative.
- Boneless, Skinless Chicken Breast (1 lb) – The main source of protein; cut into bite-sized pieces for even cooking.
- Low-Moisture Mozzarella Cheese (½ cup) – Brings melty texture to the dish; feel free to substitute with your favorite cheese.
- Parmesan Cheese (⅔ cup) – Adds a sharp, cheesy flavor; essential for that golden, bubbly topping.
- Artichoke Hearts (1 can, 16 oz, drained) – Provides a unique flavor and texture; rinse well to reduce tanginess.
- Frozen Chopped Spinach (6 oz, thawed) – Main vegetable ingredient; make sure it’s well-drained to prevent a watery casserole.
Now that you have all the ingredients for your Spinach and Artichoke Chicken Casserole, let’s bring this comfort food masterpiece to life!
Step‑by‑Step Instructions for Spinach and Artichoke Chicken Casserole
Step 1: Preheat the Oven
Begin by preheating your oven to 350°F (175°C). This ensures the heat is evenly distributed when your Spinach and Artichoke Chicken Casserole is ready to bake. While the oven warms up, prepare your ingredients to streamline the process.
Step 2: Season the Chicken
In a bowl, season the cubed boneless, skinless chicken breast with kosher salt. Let it sit at room temperature for about 20 minutes if you have the time; this dry brining method helps enhance flavor and moisture. Meanwhile, gather your other ingredients for easy access.
Step 3: Prepare the Artichokes and Spinach
Drain the can of artichoke hearts and finely chop them, setting them aside for later. Next, take your thawed frozen chopped spinach and squeeze out any excess moisture. Well-draining the spinach is crucial to prevent a watery casserole after baking.
Step 4: Cook the Chicken
Heat 1 teaspoon of avocado oil in a large non-stick skillet over medium heat. Add the seasoned chicken pieces and cook for about 2-3 minutes on each side until they are mostly cooked through and lightly golden. Once done, remove the chicken from the pan and set it aside to cool slightly.
Step 5: Blend the Cheese Mixture
In a food processor, combine 16 ounces of cottage cheese, 2 minced garlic cloves, ½ teaspoon kosher salt, ¼ teaspoon black pepper, and ¼ teaspoon onion powder. Pulse until the mixture reaches a smooth, creamy consistency. This blended mixture will add a rich texture to your casserole.
Step 6: Combine Ingredients in Baking Dish
In a large mixing bowl, combine the cooked chicken, well-drained spinach, chopped artichokes, the creamy cottage cheese blend, and ⅔ cup each of low-moisture mozzarella and parmesan cheese. Stir everything together thoroughly, then spread the mixture evenly into a greased 9×13-inch baking dish.
Step 7: Bake Covered
Cover the baking dish with aluminum foil and place it in your preheated oven. Bake for 20 minutes, allowing the flavors to meld and the casserole to heat through while keeping the moisture trapped inside.
Step 8: Add More Cheese and Bake Uncovered
After 20 minutes, remove the foil and evenly sprinkle the remaining cheese on top of the casserole. Bake uncovered for an additional 10 minutes or until the cheese is bubbly and lightly golden. If you like a crispier topping, you can broil it for 2-3 minutes at the end for that perfect finish.

Storage Tips for Spinach and Artichoke Chicken Casserole
- Fridge: Store leftover Spinach and Artichoke Chicken Casserole in an airtight container in the fridge for up to 3 days. Allow it to cool completely before sealing to maintain freshness.
- Freezer: Freeze the casserole in a freezer-safe container for up to 2 months. To prevent freezer burn, wrap it tightly in plastic wrap before placing it in a sealed bag.
- Reheating: When ready to enjoy, thaw overnight in the fridge, then reheat in the oven at 350°F (175°C) for about 20-25 minutes, or until heated through. Microwave is an option too—heat on low power, stirring occasionally.
- Serving Suggestions: Pair your reheated casserole with a side salad or toasted whole grain bread for a satisfying meal that feels fresh and delicious!
What to Serve with High-Protein Spinach and Artichoke Chicken Casserole
Elevate your dining experience by pairing this hearty casserole with complementary sides that harmonize its rich flavors.
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Creamy Mashed Potatoes: Their smooth, buttery texture contrasts beautifully with the casserole’s richness, making every bite a comforting delight.
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Garlic Bread: This crispy, garlicky delight brings a satisfying crunch, perfect for scooping up the creamy layers of the casserole.
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Caesar Salad: Crisp romaine and tangy dressing refresh the palate, cutting through the casserole’s creaminess for a well-rounded meal.
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Steamed Asparagus: This light, tender veggie adds a touch of freshness, enhancing your dish with a nutritious green element.
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Quinoa Pilaf: Nutty, fluffy quinoa pairs surprisingly well, soaking up extra flavors from the casserole, while providing a healthy grain option.
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Roasted Brussels Sprouts: The caramelized sweetness and slight bitterness of roasted Brussels sprouts create a delightful contrast with the cheesy casserole.
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Iced Herbal Tea: A crisp, refreshing drink that will cleanse your palate and keep you cool while savoring the warmth of the casserole.
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Lemon Sorbet: Finish off your meal with a light dessert that offers bright acidity, balancing the richness of the casserole beautifully.
Spinach and Artichoke Chicken Casserole Variations
Feel free to explore these delightful twists that will make your casserole even more exciting!
- Greek Yogurt: Substitute cottage cheese with Greek yogurt for added creaminess and a zesty kick.
- Fresh Spinach: Swap frozen spinach for fresh, wilting it down just before adding it to the mix for vibrant flavor.
- Cheese Medley: Try mixing in different cheeses like feta or ricotta for a Mediterranean twist that brightens the dish.
- Spicy Kick: Add red pepper flakes or diced jalapeños to kick up the heat and deliver a punch of flavor.
- Veggie Boost: Incorporate diced bell peppers or mushrooms to increase nutrition and add texture. This can transform your casserole into a veggie-packed delight!
- Herb Infusion: Sprinkle in fresh herbs like thyme or basil for a fragrant touch that elevates the dish. The freshness will be incredibly uplifting!
- Nuts for Crunch: Top with crushed pecans or walnuts before baking for a delightful crunch that contrasts the creamy filling.
- Low-Carb Option: Replace chicken with zucchini noodles for a lighter, veggie-rich casserole that’ll keep you feeling great. The flavors will still shine through!
For an added flavor profile, you might also enjoy pairing your casserole with a refreshing side like an Avocado Mojo Chicken or warming it up with a spicy dish like Shawarma Chicken Rice. Enjoy making this casserole your own!
Make Ahead Options
These High-Protein Spinach and Artichoke Chicken Casseroles are fantastic for meal prep! You can prepare the entire casserole up to 24 hours in advance by assembling it in your baking dish, covering it tightly with aluminum foil, and storing it in the refrigerator. This method allows the flavors to meld beautifully, ensuring a delicious dish when it’s time to bake. To maintain its quality, be sure to squeeze out any excess moisture from the spinach and artichokes before mixing. When you’re ready to serve, simply bake it straight from the fridge, adding an extra 5-10 minutes to the baking time for perfectly bubbly, cheesy goodness without any stress during busy weeknights!
Expert Tips for Spinach and Artichoke Chicken Casserole
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Proper Chicken Preparation: Seasoning cubed chicken and letting it sit at room temperature enhances flavor and moisture. Avoid skipping this step for a juicy result.
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Drain Your Veggies: Always squeeze excess moisture from spinach and artichokes to prevent a watery casserole. Well-drained ingredients lead to the perfect texture.
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Cheese Choices: Feel free to experiment with different cheeses. While low-moisture mozzarella and parmesan are ideal, trying feta or ricotta can add a unique twist to your Spinach and Artichoke Chicken Casserole.
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Ease of Cleanup: Using a single baking dish not only makes cooking easier but also reduces the burden of cleanup. Keep things simple and efficient!
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Melted Perfection: For an extra creamy casserole, opt for blending cottage cheese until smooth. This will create a rich, velvety mixture that elevates the flavor—perfect for family gatherings.

Spinach and Artichoke Chicken Casserole Recipe FAQs
What should I look for when choosing spinach and artichokes?
Absolutely! When selecting spinach, opt for vibrant green leaves; avoid anything that appears wilted or yellowed. For artichoke hearts, look for canned varieties that are packed in water or oil without added preservatives. Drain and rinse them well to cut down on any overly tangy taste.
How should I store leftovers of the casserole?
Leftover Spinach and Artichoke Chicken Casserole can be stored in an airtight container in the fridge for about 3 days. Ensure it has cooled completely before sealing it. This will help retain its creamy texture and prevent moisture loss. Simply reheat in the oven or microwave when you’re ready to enjoy it again!
Can I freeze this casserole, and if so, how?
Definitely! You can freeze the casserole for up to 2 months. I recommend cooling it completely, then wrapping it tightly in plastic wrap. Transfer it into a freezer-safe container or bag for extra protection against freezer burn. When you’re ready to eat, just thaw in the fridge overnight and reheat in the oven at 350°F (175°C) until warmed through—about 20-25 minutes should do the trick!
What if my casserole turns out watery?
Very often, excess moisture from the spinach and artichokes leads to a watery casserole. To avoid this, make sure to squeeze out all excess liquid from thawed spinach and well-drain artichokes. If you find it appears watery after baking, you can try broiling it for a few minutes to evaporate some moisture.
Can I modify this recipe for dietary restrictions?
Yes, you can! This casserole is both gluten-free and low-carb, making it suitable for various dietary needs. If you’re dairy-free, feel free to substitute cottage cheese with a plant-based yogurt or nut cheese. Just ensure to check any ingredient labels to keep it aligned with your dietary requirements.

Spinach and Artichoke Chicken Casserole That Wows!
Ingredients
Equipment
Method
- Preheat your oven to 350°F (175°C).
- In a bowl, season the cubed chicken with kosher salt and let it sit for 20 minutes.
- Drain and finely chop the artichoke hearts and squeeze excess moisture from the spinach.
- Heat avocado oil in a skillet over medium heat and cook the chicken for 2-3 minutes on each side until golden.
- Blend cottage cheese, minced garlic, kosher salt, black pepper, and onion powder until smooth using a food processor.
- Combine cooked chicken, spinach, chopped artichokes, and the cheese mixture in a bowl, and stir well.
- Spread the mixture in a greased baking dish and cover with aluminum foil.
- Bake for 20 minutes, then uncover and sprinkle remaining cheese on top and bake for another 10 minutes.

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